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![]() venous leg ulcer (VLU), diabetic foot ulcer (DFU) and pressure ulcer (PRU). In this study, we found a strong correlation between decreased collagen area and presence of senescent cells in human chronic wounds i.e. ![]() ![]() However, determining the presence of senescent cells would require invasive procedures such as tissue biopsies to be taken. It was previously shown that accumulation of 15% or more of senescent cells in a chronic wound edge is an indicator that the wound is unlikely to heal. Early treatment interventions for non-healing wounds are vital. High prevalence of non-healing chronic wounds contributes to a huge healthcare burden across the world.
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